[{"abbreviation":null,"activity":false,"boundaryCondition":false,"bounds":{"height":221.0,"width":228.0,"x":15541.25,"y":1659.6875,"z":26619},"compartmentId":20592,"complexId":null,"constant":false,"elementId":"csa205","formerSymbols":[],"formula":null,"fullName":null,"glyph":null,"hierarchyVisibilityLevel":"1","homomultimer":1,"hypothetical":false,"id":20871,"initialAmount":0.0,"initialConcentration":null,"linkedSubmodel":null,"modelId":7,"name":"s654","notes":"","other":{"modifications":[],"structuralState":null,"structures":{}},"references":[{"link":"https://www.ncbi.nlm.nih.gov/pubmed/16878026","article":{"title":"HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.","authors":["Yu M"," Wang H"," Ding A"," Golenbock DT"," Latz E"," Czura CJ"," Fenton MJ"," Tracey KJ"," Yang H."],"journal":"Shock (Augusta, Ga.)","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16878026","pubmedId":"16878026","citationCount":478},"type":"PUBMED","resource":"16878026","id":108204,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/23681101","article":{"title":"The history of Toll-like receptors - redefining innate immunity.","authors":["O'Neill LA"," Golenbock D"," Bowie AG."],"journal":"Nature reviews. Immunology","year":2013,"link":"https://www.ncbi.nlm.nih.gov/pubmed/23681101","pubmedId":"23681101","citationCount":625},"type":"PUBMED","resource":"23681101","id":108205,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/12620219","article":{"title":"Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members.","authors":["Janssens S"," Beyaert R."],"journal":"Molecular cell","year":2003,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12620219","pubmedId":"12620219","citationCount":319},"type":"PUBMED","resource":"12620219","id":108206,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/14660645","article":{"title":"Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein.","authors":["Park JS"," Svetkauskaite D"," He Q"," Kim JY"," Strassheim D"," Ishizaka A"," Abraham E."],"journal":"The Journal of biological chemistry","year":2004,"link":"https://www.ncbi.nlm.nih.gov/pubmed/14660645","pubmedId":"14660645","citationCount":938},"type":"PUBMED","resource":"14660645","id":108207,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/21372296","article":{"title":"High-mobility group box-1 mediates toll-like receptor 4-dependent angiogenesis.","authors":["Lin Q"," Yang XP"," Fang D"," Ren X"," Zhou H"," Fang J"," Liu X"," Zhou S"," Wen F"," Yao X"," Wang JM"," Su SB."],"journal":"Arteriosclerosis, thrombosis, and vascular biology","year":2011,"link":"https://www.ncbi.nlm.nih.gov/pubmed/21372296","pubmedId":"21372296","citationCount":56},"type":"PUBMED","resource":"21372296","id":108208,"annotatorClassName":""}],"symbol":null,"synonyms":[],"transparencyLevel":"1","type":"Complex"},{"abbreviation":null,"activity":false,"boundaryCondition":false,"bounds":{"height":25.0,"width":70.0,"x":2417.5,"y":5785.0,"z":45611},"compartmentId":21289,"complexId":null,"constant":false,"elementId":"sa1253","formerSymbols":["IFNB2"],"formula":null,"fullName":"interleukin 6","glyph":null,"hierarchyVisibilityLevel":"1","homomultimer":1,"hypothetical":false,"id":21388,"initialAmount":0.0,"initialConcentration":null,"linkedSubmodel":null,"modelId":7,"name":"IL6","notes":"
Map modules:
\n\nMAP:MACROPHAGE, MAP:MDSC
\n\nMODULE:EFFECTOR_INHIBITION, MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION, MODULE:IMMUNE_SUPPRESSION
\n\nCASCADE:STING, CASCADE:TLR2_4
\n\nReferences:
\n\nPMID:17485448
\n\nInhibition of NFkB signaling downstream of ABIN3
\n\ninhibits expression of IL8, IL6, TNF, IL12
\n\nPMID:15749903, PMID:16413922
\n\nNFKBID (IkBNS) interacts with NFkB p50 inhibit recrutement NFkB p50/p65 to IL-6 promoter
\n\nand inhibit IL6 expression.
\n\nPMID:9743347
\n\nIL-13 blocks NF-kB-dependent production of IL6
\n\nPMID:16243976
\n\nIRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
\n\nPMID:20093776
\n\nMembrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells via TLR2/MyD88 dependent IL6 expression.
\n\nPMID:18977329
\n\nIL-1B activates MDSC in vitro and in vivo through an IL-1RI/NF-kB pathway.
\n\nmRNA expression of several NF-kB target genes such is IL6, IL1B,TNF are IL1B/NFkB dependent in MSDC
\n\nPMID:17942936
\n\nIL-6 is a downstream mediator of the IL-1beta-induced expansion of MDSC
\n\nPMID:17485448, PMID:10542212
\n\nInhibition of NfkB signaling downstream of ABIN3 inhibits expression of IL8, IL6, TNFa, IL12p40
\n\nPMID: 23986532
\n\nSTING ablation abolished hallmark TGF-B and IL-10 regulatory cytokine induction (mRNA)by apoptotic cells, and proinflammatory IL-6 mRNA was expressed instead in DCs
\nRecName: Full=Interleukin-6; Short=IL-6; AltName: Full=B-cell stimulatory factor 2; Short=BSF-2; AltName: Full=CTL differentiation factor; Short=CDF; AltName: Full=Hybridoma growth factor; AltName: Full=Interferon beta-2; Short=IFN-beta-2; Flags: Precursor;\n","other":{"modifications":[],"structuralState":null,"structures":{}},"references":[{"link":"https://www.ncbi.nlm.nih.gov/pubmed/17485448","article":{"title":"ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions.","authors":["Weaver BK"," Bohn E"," Judd BA"," Gil MP"," Schreiber RD."],"journal":"Molecular and cellular biology","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17485448","pubmedId":"17485448","citationCount":31},"type":"PUBMED","resource":"17485448","id":108405,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/9743347","article":{"title":"IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1, and apoptosis.","authors":["Manna SK"," Aggarwal BB."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":1998,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9743347","pubmedId":"9743347","citationCount":39},"type":"PUBMED","resource":"9743347","id":108406,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/15749903","article":{"title":"The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria.","authors":["Hirotani T"," Lee PY"," Kuwata H"," Yamamoto M"," Matsumoto M"," Kawase I"," Akira S"," Takeda K."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2005,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15749903","pubmedId":"15749903","citationCount":107},"type":"PUBMED","resource":"15749903","id":108407,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/16413922","article":{"title":"IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation.","authors":["Kuwata H"," Matsumoto M"," Atarashi K"," Morishita H"," Hirotani T"," Koga R"," Takeda K."],"journal":"Immunity","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16413922","pubmedId":"16413922","citationCount":87},"type":"PUBMED","resource":"16413922","id":108408,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/10542212","article":{"title":"Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding.","authors":["Schottelius AJ"," Mayo MW"," Sartor RB"," Baldwin AS."],"journal":"The Journal of biological chemistry","year":1999,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10542212","pubmedId":"10542212","citationCount":290},"type":"PUBMED","resource":"10542212","id":108409,"annotatorClassName":""},{"link":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/6018","type":"HGNC","resource":"6018","id":110551,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/16243976","article":{"title":"Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS.","authors":["Honma K"," Udono H"," Kohno T"," Yamamoto K"," Ogawa A"," Takemori T"," Kumatori A"," Suzuki S"," Matsuyama T"," Yui K."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":2005,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16243976","pubmedId":"16243976","citationCount":67},"type":"PUBMED","resource":"16243976","id":108411,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/18977329","article":{"title":"Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice.","authors":["Tu S"," Bhagat G"," Cui G"," Takaishi S"," Kurt-Jones EA"," Rickman B"," Betz KS"," Penz-Oesterreicher M"," Bjorkdahl O"," Fox JG"," Wang TC."],"journal":"Cancer cell","year":2008,"link":"https://www.ncbi.nlm.nih.gov/pubmed/18977329","pubmedId":"18977329","citationCount":425},"type":"PUBMED","resource":"18977329","id":108412,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/20093776","article":{"title":"Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells.","authors":["Chalmin F"," Ladoire S"," Mignot G"," Vincent J"," Bruchard M"," Remy-Martin JP"," Boireau W"," Rouleau A"," Simon B"," Lanneau D"," De Thonel A"," Multhoff G"," Hamman A"," Martin F"," Chauffert B"," Solary E"," Zitvogel L"," Garrido C"," Ryffel B"," Borg C"," Apetoh L"," Rébé C"," Ghiringhelli F."],"journal":"The Journal of clinical investigation","year":2010,"link":"https://www.ncbi.nlm.nih.gov/pubmed/20093776","pubmedId":"20093776","citationCount":420},"type":"PUBMED","resource":"20093776","id":108403,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/gene/3569","type":"ENTREZ","resource":"3569","id":110552,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/17942936","article":{"title":"Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression.","authors":["Bunt SK"," Yang L"," Sinha P"," Clements VK"," Leips J"," Ostrand-Rosenberg S."],"journal":"Cancer research","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17942936","pubmedId":"17942936","citationCount":356},"type":"PUBMED","resource":"17942936","id":108404,"annotatorClassName":""},{"link":"https://purl.uniprot.org/uniprot/P05231","type":"UNIPROT","resource":"P05231","id":110553,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.ensembl.org/id/ENSG00000136244","type":"ENSEMBL","resource":"ENSG00000136244","id":110554,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=IL6","type":"HGNC_SYMBOL","resource":"IL6","id":108410,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/protein/NM_000600","type":"REFSEQ","resource":"NM_000600","id":110555,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":null,"type":"PUBMED","resource":"","id":108413,"annotatorClassName":""}],"symbol":"IL6","synonyms":["BSF2","HGF","HSF","IL-6"],"transparencyLevel":"0","type":"Gene"},{"abbreviation":null,"activity":false,"boundaryCondition":false,"bounds":{"height":40.0,"width":80.0,"x":2860.0,"y":4820.0,"z":38429},"compartmentId":21289,"complexId":null,"constant":false,"elementId":"sa2509","formerSymbols":["MUM1"],"formula":null,"fullName":"interferon regulatory factor 4","glyph":null,"hierarchyVisibilityLevel":"1","homomultimer":1,"hypothetical":false,"id":21507,"initialAmount":0.0,"initialConcentration":null,"linkedSubmodel":null,"modelId":7,"name":"IRF4","notes":"RecName: Full=Interferon regulatory factor 4; Short=IRF-4; AltName: Full=Lymphocyte-specific interferon regulatory factor; Short=LSIRF; AltName: Full=Multiple myeloma oncogene 1; AltName: Full=NF-EM5;","other":{"modifications":[],"structuralState":null,"structures":{}},"references":[{"link":"https://www.ensembl.org/id/ENSG00000137265","type":"ENSEMBL","resource":"ENSG00000137265","id":110912,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/6119","type":"HGNC","resource":"6119","id":110913,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://purl.uniprot.org/uniprot/Q15306","type":"UNIPROT","resource":"Q15306","id":110914,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.ncbi.nlm.nih.gov/protein/NM_001195286","type":"REFSEQ","resource":"NM_001195286","id":110915,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.ncbi.nlm.nih.gov/gene/3662","type":"ENTREZ","resource":"3662","id":110916,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=IRF4","type":"HGNC_SYMBOL","resource":"IRF4","id":110917,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"}],"symbol":"IRF4","synonyms":["LSIRF"],"transparencyLevel":"0","type":"Protein"},{"abbreviation":null,"activity":false,"boundaryCondition":false,"bounds":{"height":158.0,"width":189.0,"x":12450.5,"y":2981.0,"z":34573},"compartmentId":21289,"complexId":null,"constant":false,"elementId":"csa265","formerSymbols":[],"formula":null,"fullName":null,"glyph":null,"hierarchyVisibilityLevel":"1","homomultimer":1,"hypothetical":false,"id":21680,"initialAmount":0.0,"initialConcentration":null,"linkedSubmodel":null,"modelId":7,"name":"IKK/TNIP3 complex","notes":"","other":{"modifications":[],"structuralState":null,"structures":{}},"references":[{"link":"https://www.ncbi.nlm.nih.gov/pubmed/17485448","article":{"title":"ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions.","authors":["Weaver BK"," Bohn E"," Judd BA"," Gil MP"," Schreiber RD."],"journal":"Molecular and cellular biology","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17485448","pubmedId":"17485448","citationCount":31},"type":"PUBMED","resource":"17485448","id":108612,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/10542212","article":{"title":"Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding.","authors":["Schottelius AJ"," Mayo MW"," Sartor RB"," Baldwin AS."],"journal":"The Journal of biological chemistry","year":1999,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10542212","pubmedId":"10542212","citationCount":290},"type":"PUBMED","resource":"10542212","id":108613,"annotatorClassName":""}],"symbol":null,"synonyms":[],"transparencyLevel":"1","type":"Complex"},{"abbreviation":null,"activity":false,"boundaryCondition":false,"bounds":{"height":25.0,"width":90.0,"x":2417.5,"y":5605.0,"z":44421},"compartmentId":21289,"complexId":null,"constant":false,"elementId":"sa1252","formerSymbols":["IFNB2"],"formula":null,"fullName":"interleukin 6","glyph":null,"hierarchyVisibilityLevel":"1","homomultimer":1,"hypothetical":false,"id":21849,"initialAmount":0.0,"initialConcentration":null,"linkedSubmodel":null,"modelId":7,"name":"IL6","notes":"Map modules:
\n\nMAP:MACROPHAGE, MAP:MDSC
\n\nMODULE:EFFECTOR_INHIBITION, MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION, MODULE:IMMUNE_SUPPRESSION
\n\nCASCADE:STING, CASCADE:TLR2_4
\n\nReferences:
\n\nPMID:17485448
\n\nInhibition of NFkB signaling downstream of ABIN3
\n\ninhibits expression of IL8, IL6, TNF, IL12
\n\nPMID:15749903, PMID:16413922
\n\nNFKBID (IkBNS) interacts with NFkB p50 inhibit recrutement NFkB p50/p65 to IL-6 promoter
\n\nand inhibit IL6 expression.
\n\nPMID:9743347
\n\nIL-13 blocks NF-kB-dependent production of IL6
\n\nPMID:16243976
\n\nIRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
\n\nPMID:20093776
\n\nMembrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells via TLR2/MyD88 dependent IL6 expression.
\n\nPMID:18977329
\n\nIL-1B activates MDSC in vitro and in vivo through an IL-1RI/NF-kB pathway.
\n\nmRNA expression of several NF-kB target genes such is IL6, IL1B,TNF are IL1B/NFkB dependent in MSDC
\n\nPMID:17942936
\n\nIL-6 is a downstream mediator of the IL-1beta-induced expansion of MDSC
\nRecName: Full=Interleukin-6; Short=IL-6; AltName: Full=B-cell stimulatory factor 2; Short=BSF-2; AltName: Full=CTL differentiation factor; Short=CDF; AltName: Full=Hybridoma growth factor; AltName: Full=Interferon beta-2; Short=IFN-beta-2; Flags: Precursor;\n","other":{"modifications":[],"structuralState":null,"structures":{}},"references":[{"link":"https://www.ncbi.nlm.nih.gov/pubmed/17485448","article":{"title":"ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions.","authors":["Weaver BK"," Bohn E"," Judd BA"," Gil MP"," Schreiber RD."],"journal":"Molecular and cellular biology","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17485448","pubmedId":"17485448","citationCount":31},"type":"PUBMED","resource":"17485448","id":108737,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/9743347","article":{"title":"IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1, and apoptosis.","authors":["Manna SK"," Aggarwal BB."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":1998,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9743347","pubmedId":"9743347","citationCount":39},"type":"PUBMED","resource":"9743347","id":108738,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/15749903","article":{"title":"The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria.","authors":["Hirotani T"," Lee PY"," Kuwata H"," Yamamoto M"," Matsumoto M"," Kawase I"," Akira S"," Takeda K."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2005,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15749903","pubmedId":"15749903","citationCount":107},"type":"PUBMED","resource":"15749903","id":108739,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/16413922","article":{"title":"IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation.","authors":["Kuwata H"," Matsumoto M"," Atarashi K"," Morishita H"," Hirotani T"," Koga R"," Takeda K."],"journal":"Immunity","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16413922","pubmedId":"16413922","citationCount":87},"type":"PUBMED","resource":"16413922","id":108740,"annotatorClassName":""},{"link":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/6018","type":"HGNC","resource":"6018","id":116505,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/16243976","article":{"title":"Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS.","authors":["Honma K"," Udono H"," Kohno T"," Yamamoto K"," Ogawa A"," Takemori T"," Kumatori A"," Suzuki S"," Matsuyama T"," Yui K."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":2005,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16243976","pubmedId":"16243976","citationCount":67},"type":"PUBMED","resource":"16243976","id":108742,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/18977329","article":{"title":"Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice.","authors":["Tu S"," Bhagat G"," Cui G"," Takaishi S"," Kurt-Jones EA"," Rickman B"," Betz KS"," Penz-Oesterreicher M"," Bjorkdahl O"," Fox JG"," Wang TC."],"journal":"Cancer cell","year":2008,"link":"https://www.ncbi.nlm.nih.gov/pubmed/18977329","pubmedId":"18977329","citationCount":425},"type":"PUBMED","resource":"18977329","id":108743,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/20093776","article":{"title":"Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells.","authors":["Chalmin F"," Ladoire S"," Mignot G"," Vincent J"," Bruchard M"," Remy-Martin JP"," Boireau W"," Rouleau A"," Simon B"," Lanneau D"," De Thonel A"," Multhoff G"," Hamman A"," Martin F"," Chauffert B"," Solary E"," Zitvogel L"," Garrido C"," Ryffel B"," Borg C"," Apetoh L"," Rébé C"," Ghiringhelli F."],"journal":"The Journal of clinical investigation","year":2010,"link":"https://www.ncbi.nlm.nih.gov/pubmed/20093776","pubmedId":"20093776","citationCount":420},"type":"PUBMED","resource":"20093776","id":108735,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/gene/3569","type":"ENTREZ","resource":"3569","id":116506,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.ncbi.nlm.nih.gov/pubmed/17942936","article":{"title":"Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression.","authors":["Bunt SK"," Yang L"," Sinha P"," Clements VK"," Leips J"," Ostrand-Rosenberg S."],"journal":"Cancer research","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17942936","pubmedId":"17942936","citationCount":356},"type":"PUBMED","resource":"17942936","id":108736,"annotatorClassName":""},{"link":"https://purl.uniprot.org/uniprot/P05231","type":"UNIPROT","resource":"P05231","id":116507,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.ensembl.org/id/ENSG00000136244","type":"ENSEMBL","resource":"ENSG00000136244","id":116508,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=IL6","type":"HGNC_SYMBOL","resource":"IL6","id":108741,"annotatorClassName":""},{"link":"https://www.ncbi.nlm.nih.gov/protein/NM_000600","type":"REFSEQ","resource":"NM_000600","id":116509,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"}],"symbol":"IL6","synonyms":["BSF2","HGF","HSF","IL-6"],"transparencyLevel":"0","type":"RNA"},{"abbreviation":null,"activity":true,"boundaryCondition":false,"bounds":{"height":40.0,"width":80.0,"x":3745.625,"y":4797.5,"z":38615},"compartmentId":21289,"complexId":null,"constant":false,"elementId":"sa2302","formerSymbols":[],"formula":null,"fullName":"hypoxia inducible factor 1 subunit alpha","glyph":null,"hierarchyVisibilityLevel":"1","homomultimer":1,"hypothetical":false,"id":22186,"initialAmount":0.0,"initialConcentration":null,"linkedSubmodel":null,"modelId":7,"name":"HIF1A","notes":"","other":{"modifications":[],"structuralState":null,"structures":{}},"references":[{"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HIF1A","type":"HGNC_SYMBOL","resource":"HIF1A","id":117320,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.ncbi.nlm.nih.gov/gene/3091","type":"ENTREZ","resource":"3091","id":117321,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.ncbi.nlm.nih.gov/protein/NM_001530","type":"REFSEQ","resource":"NM_001530","id":117322,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://purl.uniprot.org/uniprot/Q16665","type":"UNIPROT","resource":"Q16665","id":117323,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/4910","type":"HGNC","resource":"4910","id":117324,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"},{"link":"https://www.ensembl.org/id/ENSG00000100644","type":"ENSEMBL","resource":"ENSG00000100644","id":117325,"annotatorClassName":"lcsb.mapviewer.annotation.services.annotators.HgncAnnotator"}],"symbol":"HIF1A","synonyms":["HIF-1alpha","HIF1","MOP1","PASD8","bHLHe78"],"transparencyLevel":"0","type":"Protein"}]